Sur-8/SHOC2抗体

产品货号：

Z27372

中文名称：

Sur-8/SHOC2抗体

英文名称：

Anti-Sur-8/SHOC2 Antibody

产品规格：

0.1mg

发货周期：

1～3天

产品价格：

询价

抗体名称	Anti-Sur-8/SHOC2 Antibody
指标别名	KIAA0862;Protein soc 2 homolog;Protein sur 8 homolog;SHOC2;SIAA0862;SOC 2;SOC2;SUR 8;SUR8;sur-8
克隆性	Polyclonal
检验物种	human,mouse,rat
应用范围	ELISA,WB,IHC
基因名称	SHOC2
抗体来源	Rabbit
抗体类型	IgG
免疫原	SHOC2 antibody was raised against a 21 amino acid synthetic peptide near the amino terminus of human SHOC2.The immunogen is located within amino acids 30 - 80 of SHOC2.
计算分子量	65kDa
成分	SHOC2 Antibody is supplied in PBS containing 0.02% sodium azide.
纯化方式	SHOC2 Antibody is affinity chromatography purified via peptide column.
浓度	1mg/mL
产品形态	溶液
保存条件	4℃可保存3个月，-20℃可保存1年。
背景资料	SHOC2 protein participates in protein binding/transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction.It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR),with a lysine-rich sequence at the amino terminus and cytoplasmically localized.SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade,which is elicited by EGL-15 and LET-23 and mediated by LET-60.SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors.Furthermore,in tumor cells with Ras gene mutations,inhibition of SHOC2 expression inhibits MAPK,but not PI3K activity.The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer.Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.
Uniprot ID	Q9UQ13
基因名全称	Soc-2 suppressor of clear homolog (C.elegans)
蛋白名全称	Soc-2 suppressor of clear homolog (C.elegans)
推荐稀释比	SHOC2 antibody can be used for detection of Shoc2 by Western blot at 1～2μg/mL.Antibody can also be used for immunohistochemistry starting at 5μg/mL.Antibody validated:Western Blot in human samples and Immunohistochemistry in human samples.All other applications and species not yet tested.

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